Optic Nerve Tumor in Tuberous Sclerosis Complex is not Responsive to Sirolimus - 05/08/11
†, ⁎ 
, David C. Wilkes, MD ‡, Catherine E. Thompson, BS , Daniel C. Bowers, MD § Division of Neurology, Texas Scottish Rite Hospital for Children, Dallas, Texas Communications should be addressed to: Dr. Sparagana; Division of Neurology; Texas Scottish Rite Hospital for Children; 2222 Welborn Street; Dallas, TX 75219.Abstract |
A 12-year-old girl with clinically established tuberous sclerosis complex, and without signs of neurofibromatosis type 1, developed a right retro-ocular optic nerve tumor. After rapid growth for 1 year after its discovery, the optic nerve tumor demonstrated modest progression. The patient received the mammalian target of rapamycin inhibitor, sirolimus, for recurrent subependymal giant cell brain tumors. Although her left ventricular subependymal giant cell tumor demonstrated a 49% reduction in volume, the optic nerve tumor did not respond, and even underwent slight (6%) growth during the 16-month treatment. The quality of this child's vision has remained normal in both eyes, and she is otherwise asymptomatic with regard to the optic nerve tumor.
Le texte complet de cet article est disponible en PDF.Plan
Vol 42 - N° 6
P. 443-446 - juin 2010 Retour au numéro
Article précédent
- Opsoclonus-Myoclonus Syndrome Attributable to Hepatitis C Infection
- Vildan Ertekin, Hüseyin Tan
- Reversible Splenial Lesion Associated With Novel Influenza A (H1N1) Viral Infection
- Aya Iwata, Kousaku Matsubara, Hiroyuki Nigami, Katsunori Kamimura, Takashi Fukaya
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?