Endoscopic techniques have influenced almost all of the surgical specialties. From open procedures to minimally invasive approaches, the endoscope and its ability to reach areas within the human body has gained popularity among specialists, creating a revolution in some fields. Two of the fields in which endoscopes provided a true revolution are otolaryngology and neurosurgery. The authors discuss some important factors for the evolution of endoscopic skull base surgery and expanded endonasal approaches, highlighting historical landmarks but also addressing the current concepts, complications, and the future of this promising field for clinical research and surgical techniques and technology.