Mother-to-Child Transmission of HIV: Pathogenesis, Mechanisms and Pathways - 05/08/11
, Marc Bulterys, MD, PhD c, d
Corresponding author. Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, MS-K34, Atlanta, GA 30341.Résumé |
More than 400,000 children were infected with (HIV-1) worldwide in 2008, or more than 1000 children per day. Mother-to-child transmission (MTCT) of HIV-1 is the most important mode of HIV acquisition in infants and children. MTCT of HIV-1 can occur in utero, intrapartum, and postnatally through breastfeeding. Great progress has been made in preventing such transmission, through the use of antiretroviral prophylactic regimens to the mother during gestation and labor and delivery and to either mother or infant during breast feeding. The timing and mechanisms of transmission, however, are multifactorial and remain incompletely understood. This article summarizes what is known about the pathogenetic mechanisms and routes of MTCT of HIV-1, and includes virologic, immunologic, genetic, and mucosal aspects of transmission.
Le texte complet de cet article est disponible en PDF.Keywords : Human immunodeficiency virus, Mother-to-child transmission, Infant, Mechanisms
Plan
| The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. |
Vol 37 - N° 4
P. 721-737 - décembre 2010 Retour au numéro
Article précédent
- Perinatal HIV and Its Prevention: Progress Toward an HIV-free Generation
- Mary Glenn Fowler, Alicia R. Gable, Margaret A. Lampe, Monica Etima, Maxensia Owor
- Viral Sequence Analysis from HIV-Infected Mothers and Infants: Molecular Evolution, Diversity, and Risk Factors for Mother-To-Child Transmission
- Philip L. Bulterys, Sudeb C. Dalai, David A. Katzenstein
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