The Brugada syndrome is a genetically determined cardiac disorder, presenting with characteristic electrocardiogram features and high risk of sudden cardiac death from polymorphic ventricular tachycardia/ventricular fibrillation in young individuals with a structurally normal heart. Scientific knowledge about the disease has grown exponentially in recent years. Two consensus reports on the disease were published (in 2002 and 2005) in an effort to state diagnostic criteria, risk stratification, and treatment indications. However, substantial controversies remain, especially considering risk stratification of asymptomatic patients. Given the enormous amount of valuable information collected by many groups since the consensus reports, current diagnostic criteria, recommended prognostic tools, and treatment must be reviewed. This article briefly reviews recent advances in understanding of Brugada syndrome and its genetic and molecular basis, arrhythmogenic mechanisms, and clinical course. An update of tools for risk stratification and treatment of the condition is also included.