Comparison of Outcomes for Patients Receiving Drug-Eluting Versus Bare Metal Stents for Non–ST-Segment Elevation Myocardial Infarction - 06/08/11
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Résumé |
The outcomes for patients undergoing percutaneous coronary interventions (PCI) with drug-eluting stents (DESs) and bare metal stents (BMSs) have been compared in many studies for patients with ST-segment elevation myocardial infarction. However, little is known about the relative outcomes for patients with non-ST-segment elevation myocardial infarction (NSTEMI). The aim of the present study was to compare the NSTEMI outcomes for PCI with DESs and BMSs. New York's PCI registry was used to propensity-match 4,776 pairs of patients with NSTEMI who had received DESs and BMSs from January 1, 2003 to December 31, 2007. These patients were followed up through December 31, 2008 to test for differences in mortality, target vessel revascularization, and total repeat revascularization. The outcomes were also compared for various patient subsets. At a median follow-up period of 3.68 years, the patients receiving DESs had significantly lower mortality (16.58% vs 14.52%, difference 2.06%, p <0.001), target vessel revascularization (13.08% vs 11.04%, p = 0.009), and total repeat revascularization (22.16% vs 18.77%, p <0.001). The patients receiving paclitaxel-eluting and sirolimus-eluting stents both experienced superior outcomes compared to patients receiving BMSs. The patients receiving DESs had significantly lower mortality rates than their propensity-matched counterparts receiving BMSs when they were ≥65 years (difference 2.29%, p = 0.01) and male (difference 2.77%, p = 0.003). In conclusion, patients with NSTEMI undergoing PCI experienced lower 4-year mortality, target vessel revascularization, and repeat revascularization rates when they had received DESs than when they had received BMSs, and patients who were >65 years old, and men received notable benefits.
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This study was funded in part by the New York State Department of Health, New York, New York. |
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The conclusions do not necessarily reflect the opinion of the New York State Department of Health. |
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A. Jacobs serves as a consultant for Xience V Everolimus Eluting Coronary Stent System (EECSS) USA Post-Approval Study. |
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S. Sharma reports that he has received a research grant from Boston Scientific Inc. and serves on a speaker's bureau for Boston Scientific Inc., Abbott Vascular, Lilly, and the Medicine Co. |
Vol 107 - N° 9
P. 1311-1318 - mai 2011 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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