Pediatric Multiple Sclerosis - 06/08/11

Doi : 10.1016/j.ncl.2011.01.004

Tanuja Chitnis, MD ^a, Lauren Krupp, MD ^b, Ann Yeh, MD ^c, Jennifer Rubin, MD ^d, Nancy Kuntz, MD ^d, Jonathan B. Strober, MD ^e, Dorothee Chabas, MD, PhD ^f, Bianca Weinstock-Guttmann, MD ^g, Jayne Ness, MD, PhD ^h,^⁎ , Moses Rodriguez, MD ⁱ, Emmanuelle Waubant, MD, PhD ^f
^a Harvard Medical School, Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children, 55 Fruit Street, Boston, MA 02114, USA
^b Department of Neurology, National Pediatric Multiple Sclerosis Center, SUNY Stony Brook, Stony Brook, NY, USA
^c Pediatric Multiple Sclerosis Center of Excellence, Jacobs Neurological Institute, SUNY-Buffalo, 219 Bryan Street, Buffalo, NY 14222, USA
^d Department of Pediatric Neurology, Children’s Memorial Hospital, Northwestern Feinberg School of Medicine, 2300 Children’s Plaza, Chicago, IL 60614, USA
^e Pediatric Muscular Dystrophy Association Clinic, Neurology and Pediatrics UCSF, Division of Child Neurology, Department of Neurology, University of California, San Francisco, Suite 609, 350 Parnassus Avenue, San Francisco, CA 94117, USA
^f Department of Neurology, UCSF Regional Pediatric Multiple Sclerosis Center, University of California, San Francisco, San Francisco, CA, USA
^g SUNY University of Buffalo, Baird Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence, Jacobs Neurological Institute, SUNY-Buffalo, 219 Bryan Street, Buffalo, NY, USA
^h University of Alabama at Birmingham, Center for Pediatric Onset Demyelinating Disease, Children’s Hospital of Alabama, 1600 7th Avenue South, CHB 314, Birmingham, AL 35233-1711, USA
ⁱ Mayo Clinc Pediatric Multiple Sclerosis Center, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA

Corresponding author.

Résumé

In the past 5 years, there has been an exponential growth in the knowledge about multiple sclerosis (MS) in children and adolescents. Recent publications have shed light on its diagnosis, pathogenesis, clinical course, and treatment. However, there remain several key areas that require further exploration. This article summarizes the current state of knowledge on pediatric MS and discusses future avenues of investigation.

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Keywords : Multiple sclerosis, Children, Pediatric, Treatment