Identification and functions of pattern-recognition receptors - 07/08/11
Reprint requests: Shizuo Akira, MD, PhD, Laboratory of Host Defense, WPI Immunology Frontier Research Center; Department of Host Defense, Research Institute for Microbial Diseases; Global COE Program, Frontier Medicine Underlying Organelle Network Biology, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.Abstract |
Since the identification of Toll-like receptors, our knowledge about pattern-recognition receptors (PRRs) has increased rapidly. Classes of PRRs that have been recently discovered include RIG-I–like receptors, Nod-like receptors, and C-type lectin receptors. Recent studies have started to clarify the molecular basis of PRR-ligand interactions, yet the numbers of PRRs and their ligands continue to increase. New technologies have elucidated the network regulation of immune responses at the cellular and in vivo levels. We review the most recent discoveries about PRRs and their ligands, their roles in intracellular and in vivo regulation of immune responses, and the systems biology of innate immunity.
Le texte complet de cet article est disponible en PDF.Key words : Pattern-recognition receptor, Toll-like receptor, RIG-I–like receptor, Nod-like receptor, C-type lectin receptor, systems biology
Abbreviations used : CARD domain, CLR, DC, ds, MyD88, NF, NLR, PAMP, poly(I:C), PRR, RLR, ROS, ss, STING, TLR, TXNIP
Plan
| Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest. |
Vol 125 - N° 5
P. 985-992 - mai 2010 Retour au numéro
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