Gender differences in asthma development and remission during transition through puberty: The TRacking Adolescents' Individual Lives Survey (TRAILS) study - 07/08/11
Reprint requests: H. Marike Boezen, PhD, Department of Epidemiology, E3.29, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RD Groningen, The Netherlands.Abstract |
Background |
During puberty, a gender shift in asthma prevalence occurs, with a preponderance of boys before puberty. The mechanisms underlying this gender shift are unclear.
Objectives |
We assessed associations of pubertal stages and transition through puberty with (1) the prevalence, incidence, and remission of asthma in male and female subjects; (2) total IgE levels; and (3) peak expiratory flow (PEF) fall during a shuttle run test (SRT).
Methods |
In the TRacking Adolescents' Individual Lives Survey study (n = 2,230; 51% female subjects), associations between pubertal stages and the prevalence, incidence, and remission of asthma were tested by using logistic regression and generalized estimating equations at a mean age of 11.1 (SD, 0.6), 13.6 (SD, 0.5), and 16.3 (SD, 0.7) years. Multiple linear regression analyses were used to study log-transformed total IgE levels and PEF fall during a SRT dependent on early versus late pubertal stages at a mean age of 16.3 years.
Results |
The prevalence of asthma was similar in boys (7.7%) and girls (7.4%) at a mean age of 11.1 years. The prevalence of asthma was significantly higher in female (6.2%) than male (4.3%) subjects at 16.3 years of age. There were no significant associations between transition of pubertal stages and the presence of asthma, either cross-sectionally or longitudinally. Pubertal stages and log-transformed total IgE levels or PEF fall during a SRT at age 16.3 years were not correlated.
Conclusions |
A shift in the prevalence of asthma occurs between 11.1 and 16.3 years, which is due to both an increased incidence and decreased remission of asthma in female compared with male subjects. Pubertal stages could not be proved to explain the gender shift in asthma prevalence.
Le texte complet de cet article est disponible en PDF.Key words : Longitudinal study, adolescents, asthma prevalence, total IgE, peak expiratory flow fall, pubertal stage
Abbreviations used : BMI, GEE, OC, PDS, PEF, SRT, TRAILS
Plan
| This research was funded by a grant of the Netherlands Asthma Foundation (grant no. 3.4.07.034). This research is embedded in TRAILS. Centers participating in TRAILS include various Departments of the University of Groningen, the Erasmus Medical Center of Rotterdam, the University of Nijmegen, the Trimbos Institute, and the University of Utrecht, The Netherlands. TRAILS is financially supported by grants from the Netherlands Organization for Scientific Research (GB-MW 940-38-011, GB-MAG 480-01-006, ZonMw 100.001.001; NWO 175.010.2003.005), the Department of Justice, and by the participating centers. |
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| Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest. |
Vol 126 - N° 3
P. 498 - septembre 2010 Retour au numéro
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