Weight reduction improves sleep, sleepiness and metabolic status in obese sleep apnoea patients - 07/08/11
, Bengt Y. Nilsson b, Liliana Mayor b, Joanna Uddén c, Stephan Rössner c, Danielle Friberg a
Corresponding author at: Karolinska University Hospital-Huddinge, ORL-dept B53, SE-141 86 Stockholm, Sweden. Tel.: +46 8 58580000; fax: +46 8 7467551.Summary |
Method |
In this prospective intervention study, 33 obese patients with obstructive sleep apnoea syndrome (OSAS) (24 men, 9 women) were consecutively enrolled for a weight reduction program at the Obesity Unit, Karolinska University Hospital. 23 of 33 patients used OSAS-device, 19 with Continuous Positive Airway Pressure and 4 with Mandibular Retaining Device. The patients were investigated with questionnaires, blood tests and ambulant nocturnal polysomnography before and after a 6-month program. Patients with OSAS-device slept without it during the sleep studies. The intervention consisted of 8 weeks low calorie diet and group meetings, followed by a day-care program of behaviour change support.
Results |
27 of 33 patients (82%, 21 men and 6 women) completed the study. After the intervention there were highly significant decreases (p<0.001) in Body Mass Index from mean(S.D.) 40(5) to 34(3), apnoea–hypopnoea index from 43(24) to 26(20) and Epworth Sleepiness Scale (ESS)-score from 9(4) to 6(4). Sleep quality (arousal index, sleep efficiency, percentage deep sleep) and metabolic status (blood pressure, blood glucose levels, lipidemia) were also significantly improved. There was a significant correlation between increased percentage deep sleep and reduced ESS-score. There were no differences due to gender or use/no use of OSAS-device.
Conclusion |
The results suggest that weight loss, induced by low calorie diet and behaviour change support, significantly improves nocturnal respiratory parameters, sleep quality, daytime sleepiness and metabolic status in obese OSAS patients after 6 months.
Le texte complet de cet article est disponible en PDF.Keywords : Sleep apnoea, Obstructive sleep apnoea, Sleep disorders, Sleepiness, Sleep quality, Sleep architecture, Sleep state, Sleep pattern, Arousal index, Obesity, Weight loss, Weight reduction, Diet, Nocturnal respiration, Polysomnography, Diabetes mellitus, Glucose, Pre-diabetes, Dyslipidemia, Blood pressure, Hypertension
Plan
Vol 2 - N° 4
P. 251-262 - décembre 2008 Retour au numéro
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