Relation Between Amygdala Structure and Function in Adolescents With Bipolar Disorder - 07/08/11
, Fei Wang, M.D., Ph.D., Lara G. Chepenik, M.D., Ph.D., Fay Y. Womer, M.D., Monique M. Jones, B.S., Brian Pittman, M.A., Maulik P. Shah, M.D., Andrés Martin, M.D., M.P.H., R. Todd Constable, Ph.D., Hilary P. Blumberg, M.D.Disclosure: Dr. Blumberg has consulted to Pfizer. The other authors report no conflicts of interest.
Abstract |
Objective |
Previous study supports the presence of reduced volume and elevated response to emotional stimuli in amygdala in adolescents with bipolar disorder (BD). In the present study, structural and functional magnetic resonance imaging scans were obtained during the same neuroimaging session to examine amygdala structure-function relations in adolescents with BD. We hypothesized that amygdala volume would be inversely associated with amygdala response to emotional stimuli, such that BD participants with the smallest amygdala volumes would exhibit the highest amygdala response.
Method |
Fifty-one adolescents (21 with BD I and 30 control adolescents, ages 10-18 years) underwent structural and functional magnetic resonance imaging scans. Amygdala volume (n = 49) and signal change (n = 44) during emotional face processing were compared between groups, and structure-function correlations were examined within the BD group (n = 16).
Results |
Adolescents with BD showed decreased amygdala volume (p = .009) and increased amygdala response to emotional faces (p = .043). There was no significant interaction between diagnosis and emotion type. A significant inverse association between amygdala volume and activation during emotional face processing was observed (r = −0.54, p = .029).
Conclusions |
Decreased volume and increased response to emotional stimuli in the amygdala in adolescents with BD are consistent with previous reports. This study represents the first report, to our knowledge, of the two findings in the same adolescent BD sample and supports an amygdala structure-function relation characterized by an inverse association between volume and response to emotional stimuli. This preliminary finding requires replication and suggests a possible pathophysiological link between abnormalities in amygdala structure and response to emotional stimuli in BD. J. Am. Acad. Child Adolesc. Psychiatry,2009;48(6):636-642.
Le texte complet de cet article est disponible en PDF.Key Words : bipolar disorder, adolescents, amygdala, magnetic resonance imaging
Plan
| This article was reviewed under and accepted by Ad Hoc Editor Daniel S. Pine, M.D. This work was supported by grants from the National Institute of Mental Health (R01MH69747 [H.P.B.], T32MH14276 [J.H.K. and L.G.C.]), the Department of Veterans Affairs Research Enhancement Award Program (H.P.B. and L.G.C.), Howard Hughes Medical Institute (M.P.S.), NARSAD (H.P.B. and J.H.K.), the Attias Family Foundation (H.P.B.), Marcia Simon Kaplan (J.H.K.), the Ethel F. Donaghue Women’s Investigator Program at Yale (H.P.B.), and the Klingenstein Foundation (J.H.K.). These data were presented in part at the 63rd Annual Scientific Meeting and Convention of the Society of Biological Psychiatry, May 1 to 3, 2008, Washington, DC. This article is dedicated to Ms. Kathleen Colonese, who was devoted to advancing research in youths with bipolar disorder and aiding the individuals with psychiatric illnesses and their families. The authors thank Karen Martin, R.T.R.M.R., Terry Hickey, R.T.R.M.R., and Hedy Sarofin, R.T.R.M.R., for technical expertise and the research subjects for their participation. The authors also thank all the members of the Mood Disorders Research Program Team. |
Vol 48 - N° 6
P. 636-642 - juin 2009 Retour au numéro
Article précédent
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