Hepatoblastoma in a Patient with Sotos Syndrome - 07/08/11
Doi : 10.1016/j.jpeds.2009.06.039
Motohiro Kato, MD a, c, Junko Takita, MD, PhD a, b, c, ⁎ 
, Kan Takahashi, MD a, Masakazu Mimaki, MD, PhD a, Yuyan Chen, MD, PhD a, Katsuyoshi Koh, MD a, Kohmei Ida, MD, PhD a, Akira Oka, MD, PhD a, Masashi Mizuguchi, MD, PhD a, d, Seishi Ogawa, MD, PhD c, Takashi Igarashi, MD, PhD a
, Kan Takahashi, MD a, Masakazu Mimaki, MD, PhD a, Yuyan Chen, MD, PhD a, Katsuyoshi Koh, MD a, Kohmei Ida, MD, PhD a, Akira Oka, MD, PhD a, Masashi Mizuguchi, MD, PhD a, d, Seishi Ogawa, MD, PhD c, Takashi Igarashi, MD, PhD a a Department of Pediatrics, Graduate school of Medicine, University of Tokyo, Tokyo, Japan
b Department of Cell Therapy and Transplantation Medicine, Graduate school of Medicine, University of Tokyo, Tokyo, Japan
c Cancer Genomicse Project, Graduate school of Medicine, University of Tokyo, Tokyo, Japan
d Department of Developmental Medical Sciences, Graduate school of Medicine, University of Tokyo, Tokyo, Japan
Reprint requests: Junko Takita, MD, PhD, University of Tokyo, Dept of Pediatrics, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.Abstract |
We report a case of hepatoblastoma that developed in a child with Sotos syndrome, an overgrowth syndrome with an increased risk of neoplasms. Genome-wide analysis of copy number alterations showed a gain of chromosome 2, uniparental disomy of 18q, and microdeletion of 5q35.
Le texte complet de cet article est disponible en PDF.Mots-clés : CITA, SNP
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| The authors declare no conflicts of interest. |
© 2009
Publié par Elsevier Masson SAS.
Vol 155 - N° 6
P. 937-939 - décembre 2009 Retour au numéro
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