National Comorbidity Survey Replication Adolescent Supplement (NCS-A): III. Concordance of DSM-IV/CIDI Diagnoses With Clinical Reassessments - 08/08/11
, Shelli Avenevoli, Ph.D., Jennifer Green, Ph.D., Michael J. Gruber, M.S., Margaret Guyer, Ph.D., Yulei He, Ph.D., Robert Jin, M.S., Joan Kaufman, Ph.D., Nancy A. Sampson, B.A., Alan M. Zaslavsky, Ph.D., Kathleen R. Merikangas, Ph.D.Disclosure: Dr. Kessler has been a consultant for GlaxoSmithKline, Kaiser Permanente, Pfizer, Sanofi-Aventis, Shire Pharmaceuticals, and Wyeth-Ayerst; has served on advisory boards for Eli Lilly and Wyeth-Ayerst; and has received research support for his epidemiological studies from Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Johnson & Johnson Pharmaceuticals, Ortho-McNeil Pharmaceuticals, Pfizer, and Sanofi-Aventis. Dr. Kaufman has served as a consultant for Bristol-Myers Squibb, Pfizer, Wyeth-Ayerst, Forest Laboratories, Johnson & Johnson Research Pharmaceutical Institute, Shire, and Otsuka Pharmaceutical. The other authors report no conflicts of interest.
Abstract |
Objective |
To report results of the clinical reappraisal study of lifetime DSM-IV diagnoses based on the fully structured lay-administered World Health Organization Composite International Diagnostic Interview (CIDI) Version 3.0 in the U.S. National Comorbidity Survey Replication Adolescent Supplement (NCS-A).
Method |
Blinded clinical reappraisal interviews with a probability subsample of 347 NCS-A respondents were administered using the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS) as the gold standard. The DSM-IV/CIDI cases were oversampled, and the clinical reappraisal sample was weighted to adjust for this oversampling.
Results |
Good aggregate consistency was found between CIDI and K-SADS prevalence estimates, although CIDI estimates were meaningfully higher than K-SADS estimates for specific phobia (51.2%) and oppositional defiant disorder (38.7%). Estimated prevalence of any disorder, in comparison, was only slightly higher in the CIDI than K-SADS (8.3%). Strong individual-level CIDI versus K-SADS concordance was found for most diagnoses. Area under the receiver operating characteristic curve, a measure of classification accuracy not influenced by prevalence, was 0.88 for any anxiety disorder, 0.89 for any mood disorder, 0.84 for any disruptive behavior disorder, 0.94 for any substance disorder, and 0.87 for any disorder. Although area under the receiver operating characteristic curve was unacceptably low for alcohol dependence and bipolar I and II disorders, these problems were resolved by aggregation with alcohol abuse and bipolar I disorder, respectively. Logistic regression analysis documented that consideration of CIDI symptom-level data significantly improved prediction of some K-SADS diagnoses.
Conclusions |
These results document that the diagnoses made in the NCS-A based on the CIDI have generally good concordance with blinded clinical diagnoses.
Le texte complet de cet article est disponible en PDF.Key Words : National Comorbidity Survey Replication Adolescent Supplement, Composite International Diagnostic Interview, mental disorders, epidemiology, validity
Plan
| The National Comorbidity Survey Replication Adolescent Supplement (NCS-A) is supported by the National Institute of Mental Health (NIMH; Grant U01-MH60220) with supplemental support from the National Institute on Drug Abuse, the Substance Abuse and Mental Health Services Administration, the Robert Wood Johnson Foundation (Grant 044780), and the John W. Alden Trust. The work of Dr. Merikangas and her staff on the NCS-A is additionally supported by the NIMH Intramural Research Program, whereas the work of Dr. Zaslavsky and his staff on the validity of the NCS-A measures is supported by NIMH Grant R01-MH66627. The views and opinions expressed in this article are those of the authors and should not be construed to represent the views of any of the sponsoring organizations, agencies, or U.S. Government. A complete list of NCS-A publications can be found at ncs. The NCS-A is performed in conjunction with the World Health Organization World Mental Health (WMH) Survey Initiative. The authors thank the staff of the WMH Coordination Centers for assistance with instrumentation, fieldwork, and consultation on data analysis. The WMH Data Coordination Centers have received support from NIMH (Grants R01-MH070884, R13-MH066849, R01-MH069864, and R01-MH077883), National Institute on Drug Abuse (Grant R01-DA016558), the Fogarty International Center of the National Institutes of Health (Grant R03-TW006481), the John D. and Catherine T MacArthur Foundation, the Pfizer Foundation, and the Pan American Health Organization. The WMH Data Coordination Centers have also received unrestricted educational grants from AstraZeneca, Bristol-Myers Squibb, Eli Lilly and Company, GlaxoSmithKline, Ortho-McNeil, Pfizer, Sanofi-Aventis, and Wyeth. A complete list of WMH publications can be found at wmh. The authors thank Steven Heeringa, Ph.D., and Alan Zaslavsky, Ph.D., as the statistical experts for this article. This article is the subject of an editorial by Dr. Peter Szatmari in this issue. |
Vol 48 - N° 4
P. 386-399 - avril 2009 Retour au numéro
Article précédent
- National Comorbidity Survey Replication Adolescent Supplement (NCS-A): II. Overview and Design
- Ronald C. Kessler, Shelli Avenevoli, E. Jane Costello, Jennifer Greif Green, Michael J. Gruber, Steven Heeringa, Kathleen R. Merikangas, Beth-Ellen Pennell, Nancy A. Sampson, Alan M. Zaslavsky
- Strengths and Difficulties Questionnaire as a Dimensional Measure of Child Mental Health
- Anna Goodman, Robert Goodman
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