Fish Oil N-3 Polyunsaturated Fatty Acids Selectively Affect Plasma Cytokines and Decrease Illness in Thai Schoolchildren: A Randomized, Double-Blind, Placebo-Controlled Intervention Trial - 08/08/11
, Suched Samuhaseneetoo, PhD b, Kathryn Popplestone, BSc c, Annette L. West, BSc c, Elizabeth A. Miles, PhD c, Philip C. Calder, PhD c
Reprint requests: Alice Thienprasert, PhD, Faculty of Science, Silpakorn University, Nakornpathom, 73000 ThailandRésumé |
Objective |
To determine whether very long–chain n-3 polyunsaturated fatty acids (PUFAs) affect illness and selected plasma cytokines in schoolchildren.
Study design |
Thai schoolchildren aged 9 to 12 years consumed milk containing placebo (soybean) oil (n = 86) or fish oil (n = 94) on 5 days per week for 6 months; the latter provided 200 mg eicosapentaenoic acid plus 1 g docosahexaenoic acid daily. Episodes and duration of illness were recorded, and plasma interleukin (IL)-2 receptor, IL-6, IL-10, and transforming growth factor (TGF)-β1 concentrations and the fatty acid profile of plasma phosphatidylcholine determined.
Results |
After intervention, very long–chain n-3 PUFAs were higher in plasma phosphatidylcholine in the fish oil group than in the placebo group (P < .001). The fish oil group showed fewer episodes (P = .014) and shorter duration (P = .024) of illness (mainly upper respiratory tract) than the placebo group. Plasma IL-2 receptor, IL-10, and IL-6 were not affected by either treatment. Plasma TGF-β1 increased in both groups, but the increase was smaller in the fish oil group, and at the end of supplementation TGF-β1 concentration was lower in the fish oil group (P < .001).
Conclusions |
Very long–chain n-3 PUFAs reduce illness, mainly infections, in healthy Thai schoolchildren.
Le texte complet de cet article est disponible en PDF.Abbreviations : DHA, DPA, ELISA, EPA, IL, PC, PUFA, sIL-2R, TGF, TNF, UHT
Plan
| Supported by a grant (R01TW006201) from the National Institutes of Health, USA to AT under the GRIP program. The authors declare no conflicts of interest. |
Vol 154 - N° 3
P. 391-395 - mars 2009 Retour au numéro
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