Pulmonary function testing in patients with pulmonary arterial hypertension - 08/08/11
, Xi-Qi Xu a, c, g, David B. Badesch d, Xin Jiang a, Yan Wu b, Jin-Ming Liu a, Yong Wang e, Lei Pan e, Hui-Ping Li a, Jie-Lin Pu b, Zhuo-Li Zhang f, Yue-Jin Yang b
Corresponding author: Department of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University, No. 507 Zhengmin Road, Shanghai 200433, China.Summary |
Background |
Although previous studies have shown that peripheral airway obstruction can occur in idiopathic PAH (IPAH), pulmonary function tests have not been well-studied in patients with PAH associated with congenital heart disease (CHD-PAH) and connective tissue disease (CTD-PAH).
Methods |
A multicenter prospective study was performed in PAH patients in China. Pulmonary function tests were evaluated in 190 PAH patients.
Results |
Total lung capacity (TLC), residual volume (RV) and total airway resistance (Rtot) were similar in PAH patients and controls. However, measures of airflow, including vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1s (FEV1), FEV1/FVC and MEF50 were decreased in PAH group. Single-breath diffusion capacity for carbon monoxide (DLCO) was also decreased in PAH patients. Expiratory flow–volume curves showed reduction and a curvilinear appearance in patients with PAH. Similar changes were observed among the various subgroups of IPAH, CHD-PAH, and CTD-PAH patients. More CTD-PAH patients had abnormal DLCO.
Conclusions |
Airway obstruction is common in IPAH, CHD-PAH and CTD-PAH patients. CTD-PAH patients have lower DLCO. Hemodynamics, serum markers and exercise capacity parameters did not correlate well with pulmonary function indices.
Le texte complet de cet article est disponible en PDF.Keywords : Airway obstruction, Pulmonary arterial hypertension, Pulmonary function test, Pulmonary diffusion capacity
Plan
Vol 103 - N° 8
P. 1136-1142 - août 2009 Retour au numéro
Article précédent
- Increased apoptosis of neutrophils in induced sputum of COPD patients
- Demosthenes Makris, Thomas Vrekoussis, Mbouloukaki Izoldi, Kalogeraki Alexandra, Darivianaki Katerina, Tamiolakis Dimitris, Alexandrakis Michalis, Eleni Tzortzaki, Nikos M. Siafakas, Nikos Tzanakis
- Correlates of osteoporosis in chronic obstructive pulmonary disease: An underestimated systemic component
- Lidwien Graat-Verboom, Martijn A. Spruit, Ben E.E.M. van den Borne, Frank W.J.M. Smeenk, Elisabeth J. Martens, Ragnar Lunde, Emiel F.M. Wouters, On behalf of the CIRO Network g
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?