Clarithromycin inhibits fibroblast migration - 08/08/11
, Yasuhiro Yamauchi a, Hajime Takizawa b, Susumu Itakura a, Sumiko Kamitani a, Jun Kato a, Takahide Nagase a
Corresponding author. Tel.: +81 03 3815 5411; fax: +81 03 3815 5954.Summary |
The aim of the current study was to investigate the effect of 14-membered ring macrolide clarithromycin (CAM) on migration induced by human plasma fibronectin (HFn) or on contraction of human fetal lung fibroblasts (HFL-1).
Methods and results |
Using the blindwell chamber technique, CAM (10−5M) inhibited the migration of HFL-1 60.2±4.0% (p<0.05). Other antibiotics, such as ampicillin, minocycline or azithromycin had no effects on HFL-1 migration. The effect of CAM was concentration dependent. HFL-1 migration, stimulated by TXA2 analog was also inhibited by CAM. Clarithromycin had no effect on HFL-1 mediated gel contraction that was another function of fibroblast at the wound area.
Conclusions |
Clarithromycin may contribute to the regulation of the wound healing response following injury by inhibiting fibroblast migration. These results could represent the therapeutic benefits of CAM.
Le texte complet de cet article est disponible en PDF.Keywords : Fibroblast, Macrolide, Clarithromycin, Migration
Plan
Vol 102 - N° 12
P. 1769-1776 - décembre 2008 Retour au numéro
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