Atopic dermatitis is a complex, chronic inflammatory skin disease. Affected individuals, particularly those with moderate to severe disease, often suffer from significant morbidity, such as sleep loss, skin infections, and school or work disruption. Treatment for these patients can be especially challenging. Restoring skin barrier function, eliminating allergic and nonallergic triggers, and properly using anti-inflammatory and antimicrobial medications are all important components of a comprehensive treatment plan. Wet wraps and systemic immunosuppressants are alternative treatments for patients with severe, refractory atopic dermatitis.