Cerebrospinal fluid levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in subacute sclerosing panencephalitis - 08/08/11
, Takeshi Matsushige a, Peter Siba b, Dagwin Suarkia b, Toshiaki Takasu c, Kenji Miki c, Susumu Furukawa a
Corresponding author. Tel.: +81 836 22 2258; fax: +81 836 22 2257.Summary |
Objectives |
To investigate the brain inflammation and damage in subacute sclerosing panencephalitis (SSPE), the cerebrospinal fluid (CSF) concentrations of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were determined in SSPE patients.
Methods |
CSF MMP-9 and TIMP-1 levels were measured in 23 patients with SSPE in Papua New Guinea by ELISA.
Results |
CSF MMP-9 levels and MMP-9/TIMP-1 ratios of SSPE patients were significantly higher than controls (p<0.001 and p=0.005, respectively). There were no significant differences in CSF TIMP-1 levels between SSPE patients and controls.
Conclusions |
Previous studies suggested that CSF MMP-9 levels reflect inflammatory damage to the brain. Our findings suggest that the MMP-9 level in CSF is an indicator of inflammatory damage to the brain in SSPE.
Le texte complet de cet article est disponible en PDF.Keywords : Cerebrospinal fluid, Matrix metalloproteinase-9, Subacute sclerosing panencephalitis, Tissue inhibitor of metalloproteinase-1
Plan
Vol 56 - N° 5
P. 376-380 - mai 2008 Retour au numéro
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