Do Proliferating Cell Nuclear Antigen and MIB-1/Ki-67 Have Prognostic Value in Penile Squamous Cell Carcinoma? - 09/08/11
, Marcos Lima de Oliveira Leal, Rodrigo Sousa Madeira Campos, Stênio de Cássio Zequi, Francisco Paulo da Fonseca, Isabela Werneck da Cunha, Fernando Augusto Soares, Ademar Lopes
Reprint requests: Gustavo Cardoso Guimarães, M.D., Department of Pelvic Surgery, Hospital do Câncer A.C. Camargo, Rua Professor Antonio Prudente 211, São Paulo 01509-010, Brazil.Résumé |
Objectives |
To evaluate the role of proliferating cell nuclear antigen (PCNA) and MIB-1/Ki-67 immunohistochemical expression in predicting lymph node metastasis and survival in primary penile squamous cell carcinoma.
Methods |
We conducted a retrospective evaluation of 125 patients with penile squamous cell carcinoma submitted to primary tumor treatment, with information on lymph node status. Clinical and pathologic data for PCNA and MIB-1/Ki-67 expression in the primary tumor were analyzed. Correlations between these data and lymph node metastasis risk and survival were calculated.
Results |
In univariate analysis, low MIB-1/Ki-67 expression, the presence of lymphovascular permeation, clinically positive lymph nodes, tumor thickness greater than 5 mm, and infiltration of cavernous bodies were correlated with lymph node metastasis. However, the independent factors for lymph node metastasis risk were PCNA and MIB-1/Ki-67 immunoreactivity, lymphovascular permeation, and N clinical stage. Independent variables for disease-free survival were urethra infiltration and the presence of lymph node metastasis. For death risk evaluation the independent variables were age, lymph node metastasis, and clinical stage.
Conclusions |
There was a correlation between PCNA and MIB1/Ki-67 immunohistochemical expression and the presence of lymph node metastasis. However, PCNA and MIB1/Ki-67 immunohistochemical expression did not have a relationship with survival and death risk.
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Vol 70 - N° 1
P. 137-142 - juillet 2007 Retour au numéro
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