Fluid-attenuated inversion-recovery MR imaging in schizophrenia-associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome) - 01/01/05
, Rei Yasukawa, M.D., Takumi Mihara, M.D., Shoichi Mizuno, M.D., Hideaki Yasuda, M.D., Tsuruhei Sukegawa, M.D., Maiko Hayashida, M.D., Takuji Inagaki, M.D., Jun Horiguchi, M.D.Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Background. - Patients with schizophrenia show a significantly higher frequency of hyperbilirubinemia the patients suffering from other psychiatric disorders and the general healthy population. The objective of the current study was to determine whether patients with schizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome, GS) have specific changes in signal intensities on fluid-attenuated inversion-recovery (FLAIR) magnetic resonance (MR) images.
Methods. - Axial 5-mm-thick FLAIR MR images from schizophrenia patients with GS (n=18) and schizophrenia patients without GS (n=18), all diagnosed according to DSM-IV criteria, were compared with age- and sex-matched non-psychiatric controls (n=18). Signal intensities in the hippocampus, amygdala, caudate, putamen, thalamus, cingulate gyrus, and insula were graded relative to cortical signal intensity in the frontal lobe.
Results. - Compared to both schizophrenia patients without GS and normal controls, the schizophrenia patients with GS showed significantly increased signal intensities in almost all regions studied.
Conclusion. - Patients with schizophrenia-associated GS have specific changes of signal intensities on FLAIR MR images, suggesting that schizophrenia with GS produces changes in the fronto-temporal cortex, limbic system, and basal ganglia.
Le texte complet de cet article est disponible en PDF.Keywords : Fluid-attenuated inversion-recovery, MR imaging, Gilbert's syndrome, Schizophrenia
Plan
Vol 20 - N° 4
P. 327-331 - juin 2005 Retour au numéro
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