Steroids for Deteriorating Herpes Simplex Virus Encephalitis - 09/08/11
, Israel Matoth, MD , Dana G. Wolf, MD †, Dan Engelhard, MD , Diana Averbuch, MD ⁎ 
Department of Pediatrics, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel Communications should be addressed to: Dr. Averbuch; Pediatric Infectious Diseases; Department of Pediatrics; Hadassah University Hospital; POB 12000; IL-91120 Jerusalem; Israel.Résumé |
A 16-month-old girl presented with herpes simplex virus type 1 encephalitis with involvement of bilateral parietofrontal lobes, left thalamus and cerebellum. She was treated with intravenous acyclovir. As her condition deteriorated, high-dose methylprednisolone was administered, resulting in remarkable improvement. This case suggests considering a short course of high-dose steroid therapy in severe herpes simplex encephalitis when there is clinical and radiologic deterioration in spite of appropriate antiviral therapy and decreasing viral load in the cerebrospinal fluid.
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Vol 37 - N° 3
P. 229-232 - septembre 2007 Retour au numéro
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