An Update on the Amyloid Hypothesis - 09/08/11
Doi : 10.1016/j.ncl.2007.03.007
Christopher B. Eckman, PhD a, ⁎ 
, Elizabeth A. Eckman, PhD b
, Elizabeth A. Eckman, PhD b a Department of Neuroscience, Mayo Clinic College of Medicine, Birdsall Building Room 306, 4500 San Pablo Road, Jacksonville, FL 32224, USA
b Department of Neuroscience, Mayo Clinic College of Medicine, Birdsall Building Room 318a, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Corresponding author.Abstract |
Alzheimer’s disease (AD) is a devastating neurodegenerative disease. To rationally develop novel therapeutic and/or preventative agents for AD, an understanding of the etiology and pathogenesis of this complex disease is necessary. This article examines the evidence for the amyloid hypothesis of AD pathogenesis and discusses how it relates to the neurological and neuropathological features of AD, the known genetic risk factors and causative mutations, and the heightened risk associated with advanced age.
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| This work was supported by grants from the National Institutes of Neurological Diseases and Stroke (NIH 5R01NS042192 and NIH 5R01NS048554) and by the Mayo Foundation for Medical Education and Research. |
© 2007
Elsevier Inc. Tous droits réservés.
Vol 25 - N° 3
P. 669-682 - août 2007 Retour au numéro
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