Advances in Melanocyte Basic Science Research - 09/08/11
Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, West Yorkshire, UK.Abstract |
This article focuses on recent advances in melanocyte biology and physiology. The major function of this neural crest–derived cell is the production of melanins. A “three enzyme theory” in the initiation of pigmentation is put forward and backed up by recent findings. A receptor-independent role for ⍺-MSH and the cofactor (6R)-l-erythro-5,6,7,8-terahydrobiopterin (6BH4) in the control of tyrosinase is described. The importance of intramelanosomal pH for melanogenesis is covered. Finally, the redundancy of the cAMP and IP3/DAG/calcium signal in melanocytes together with the downstream events are highlighted. The main message of this article is that the intracellular H2O2- redox-equilibrium controls melanocyte function in a concentration-dependent manner.
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Vol 25 - N° 3
P. 283-291 - juillet 2007 Retour au numéro
Article précédent
- The Melanocyte and the Epidermal Melanin Unit: An Expanded Concept
- James J. Nordlund
- Evolutionary, Biologic, and Social Aspects of Skin Color
- Wiete Westerhof
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