Cytoreductive Partial Nephrectomy Does Not Undermine Cancer Control in Metastatic Renal Cell Carcinoma: A Population-Based Study - 09/08/11
Reprint requests: Pierre I. Karakiewicz, MD, Cancer Prognostics and Health Outcomes Unit, University of Montreal, Health Center (CHUM), 1058 Rue St.-Denis, Montréal, QC, Canada, H2X 3J4Résumé |
Objectives |
We examined the population-based rates of cancer-specific survival in patients with metastatic renal cell carcinoma (MRCC) treated with either partial (PN) or radical cytoreductive nephrectomy (RN).
Methods |
Patients diagnosed with MRCC and treated with either PN or RN were identified within nine SEER cancer registries. Matched and unmatched Kaplan-Meier survival analyses, as well as multivariable Cox regression models compared the effect of RN (n = 1997, 97.8%) vs. PN (n = 46, 2.2%) on cancer-specific survival (CSS). Covariates consisted of age, gender, community type (rural vs urban), race, Surveillance, Epidemiology, and End Results (SEER) registry, tumor size and year of diagnosis.
Results |
In multivariable unmatched Cox regression analyses, no statistically significantly difference was found in CSS between the two groups (hazard ratio [HR] 1.40, P = .16). Similarly, no difference in CSS was found in the matched analyses (HR 1.35, log rank P = .34).
Conclusion |
Cytoreductive PN does not appear to undermine survival in patients with MRCC.
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| Pierre I. Karakiewicz is partially supported by the University of Montreal Urology Associates, Fonds de la Recherche en Santé du Québec, the University of Montreal Department of Surgery, and the University of Montreal Foundation. Laurent Zini is partially supported by the Association Française de Recherche sur le Cancer, the Fondation de France—Fédération Nationale des Centres de Lutte Contre le Cancer, the Association Française d'Urologie, and the Ministère Français des Affaires Etrangères et Européennes (Bourse Lavoisier). |
Vol 72 - N° 5
P. 1090-1095 - novembre 2008 Retour au numéro
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