A 21st Century HPLC Workflow for Process R&D - 09/08/11
Corresponding author.Abstract |
A unique high-performance liquid chromatographic (HPLC) workflow specifically designed for the rigors of process development has been developed. A key feature of the workflow is the creation of an HPLC software-hardware platform designed to automatically and systematically screen samples using a matrix of columns and eluents to aggressively search for impurities. The workflow platform was assembled from commercial hardware components and both custom and commercial HPLC software. The platform can be used to challenge existing HPLC methods or to develop new methods. Three real world examples are provided to illustrate the utility of the platform to rigorously assess the complexity of samples and to develop new and improved HPLC methods.
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| This article was originally published in JALA; December 2005. |
Vol 27 - N° 1
P. 93-111 - mars 2007 Retour au numéro
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