Innate and adaptive immunity and the pathophysiology of psoriasis - 09/08/11
Baltimore, Maryland
Abstract |
Psoriasis is considered to be a genetically programmed disease of dysregulated inflammation, which is driven and maintained by multiple components of the immune system. The pathologic collaboration between innate immunity (mediated by antigen-presenting cells and natural killer T lymphocytes) and acquired immunity (mediated by T lymphocytes) results in the production of cytokines, chemokines, and growth factors that contribute to the inflammatory infiltrate seen in psoriatic plaques. This overview of the pathophysiology of psoriasis describes these events, and recent developments that have contributed to our understanding of the role of immune function in psoriasis. These developments include the creation of useful animal models and identification of new receptors and lymphocyte subtypes that may participate in the development of this chronic disease.
Le texte complet de cet article est disponible en PDF.Abbreviations used : APC, CCL, CCR, CXCR, DC, HSP, IFN, IL, IP, KC, MDC, MIG, MIP, NK, NKT, RANTES, TARC, TCR, Th, TLR, TNF
Plan
Supported by Amgen Inc and Wyeth Research, and National Institutes of Health Grant 1 R01 AR050029-01 A2. Disclosure: This review article was solicited for this supplement by Amgen Inc. Dr Gaspari received an honorarium for this article. During the past 5 years, he has been a paid consultant, received honoraria, and performed clinical trials for Amgen. Reprints not available from the author. |
Vol 54 - N° 3S2
P. S67-S80 - mars 2006 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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