Comparative Effects of Methylphenidate and Mixed Salts Amphetamine on Height and Weight in Children With Attention-Deficit/Hyperactivity Disorder - 09/08/11
, THOMAS L. MATTHEWS, M.D., KENNETH J. BRASLOW, M.D., MELISSA A. WATSON, M.D.ABSTRACT |
Objective |
To determine whether methylphenidate (MPH) and mixed salts amphetamine (MSA) have different effects on growth in children with attention-deficit/hyperactivity disorder.
Method |
Patients treated for at least 1 year with MPH or MSA were identified. A linear regression was performed to determine the effect of stimulant type, patient gender, cumulative stimulant dose, and length of time in treatment on change in Z scores for height. A subset of patients was identified who had 3 years of consistent stimulant treatment on either MSA or MPH. Repeated-measures analyses of variance were performed to examine the effects of time and medication type on Z scores for weight, height, and body mass index.
Results |
The linear regression showed no effect of stimulant type, drug holidays, or length of time of treatment on change in height Z score. Cumulative dose of stimulant had a small (−0.26) relationship to change in height Z scores. For patients treated for 3 years, there were no effects of stimulant or time on height Z scores. MSA produced more decrease in weight and body mass index Z scores than MPH; all of the subjects were heavier than average at baseline.
Conclusion |
MSA and MPH did not differ in their effects on height. MSA had more of an effect on weight than MPH, although the effect was modest in magnitude and may be of limited clinical significance.
Le texte complet de cet article est disponible en PDF.Key Words : attention-deficit/hyperactivity disorder, methylphenidate, mixed salts amphetamine, stimulants, growth
Plan
| Disclosure: Dr. Pliszka serves on the speakerapos;s bureau of Shire Pharmaceutical and McNeil Pharmaceuticals and has also received research support from Eli Lilly, Cephalon, and UCB Pharma. The other authors have no financial relationships to disclose. |
Vol 45 - N° 5
P. 520-526 - mai 2006 Retour au numéro
Article précédent
- Sleep Hygiene and Melatonin Treatment for Children and Adolescents With ADHD and Initial Insomnia
- MARGARET D. WEISS, MICHAEL B. WASDELL, MELISSA M. BOMBEN, KATHLEEN J. REA, ROGER D. FREEMAN
- Does Prolonged Therapy With a Long-Acting Stimulant Suppress Growth in Children With ADHD?
- THOMAS J. SPENCER, STEPHEN V. FARAONE, JOSEPH BIEDERMAN, MARC LERNER, KIMBERLY M. COOPER, BRENDA ZIMMERMAN, ON BEHALF OF THE CONCERTA STUDY GROUP
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?