Plant stanols do not restore endothelial function in pre-pubertal children with familial hypercholesterolemia despite reduction of low-density lipoprotein cholesterol levels - 10/08/11
, Maud N. Vissers, PhD, Jessica Rodenburg, MD, PhD, Albert Wiegman, MD, PhD, Mieke D. Trip, MD, PhD, John J.P. Kastelein, MD, PhD
Reprint requests: Lily Jakulj, Academic Medical Centre, Department of Vascular Medicine, University of Amsterdam, Meibergdreef 9 – Room F4-159.2, 1105 AZ Amsterdam.Résumé |
Objective |
To examine the effect of plant stanols on lipids and endothelial function in pre-pubertal children with familial hypercholesterolemia (FH).
Study design |
Children with FH (n = 42), aged 7-12 years, were enrolled in a double-blind crossover trial, in which they consumed 500 mL of a low-fat yogurt enriched with 2.0 g of plant stanols and 500 mL of a low-fat placebo yogurt for 4 weeks, separated by a 6-week washout period. Lipid profiles and endothelial function were assessed after both consumption periods. Endothelial function was measured as flow-mediated dilation (FMD) of the brachial artery.
Results |
This daily intake of 2.0 g of stanols significantly decreased the levels of total cholesterol (TC) by 7.5% and low-density lipoprotein cholesterol (LDL-C) by 9.2% as compared with placebo. High-density lipoprotein cholesterol and triglyceride levels remained unaltered. The reduction of LDL-C levels did not improve FMD, which was 10.5% ± 5.1% after plant stanol consumption and 10.6% ± 5.0% after placebo consumption, respectively (P = .852).
Conclusion |
This study demonstrates that plant stanols reduce LDL-C levels in children with FH without improving endothelial function.
Le texte complet de cet article est disponible en PDF.Abbreviations : FH, FMD, HDL-C, LDL-C, NCEP, TC, TG
Plan
Vol 148 - N° 4
P. 495-500 - avril 2006 Retour au numéro
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