Folinic Acid–Responsive Seizures Initially Responsive to Pyridoxine - 10/08/11
Doi : 10.1016/j.pediatrneurol.2005.08.019
Joost Nicolai, MD 
⁎ 
, Vivianne H.J.M. van Kranen-Mastenbroek, MD, PhD †, Ron A. Wevers, PhD ‡, Wilfred A.P.T. Hurkx, MD §, Johan S.H. Vles, MD, PhD
Department of Neurology University Hospital Maastricht, Maastricht
⁎ , Vivianne H.J.M. van Kranen-Mastenbroek, MD, PhD †, Ron A. Wevers, PhD ‡, Wilfred A.P.T. Hurkx, MD §, Johan S.H. Vles, MD, PhD Department of Neurology University Hospital Maastricht, Maastricht † Department of Clinical Neurophysiology, University Hospital Maastricht, Maastricht
‡ Laboratory of Pediatrics and Neurology, Institute of Neurology, Radboud University Nijmegen Medical Center, Nijmegen
§ Department of Pediatrics, Elkerliek Hospital, Helmond, the Netherlands.
Communications should be addressed to: Dr. Nicolai; Department of Neurology; University Hospital Maastricht; PO Box 5800; 6202 AZ Maastricht, the Netherlands.Résumé |
This report presents a male who developed clonic seizures on the day he was born. The next day, the diagnosis of pyridoxine-dependent seizures was made. However, contradictory to this diagnosis, seizures reappeared despite treatment with pyridoxine. Seizures ceased after folinic acid was initiated. The clinical and biochemical characteristics of folinic acid–responsive seizures are reviewed. Treatment with folinic acid should be considered in neonatal seizures of unknown origin that do not respond to pyridoxine, or manifest a transient response to pyridoxine.
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© 2006
Elsevier Inc. Tous droits réservés.
Vol 34 - N° 2
P. 164-167 - février 2006 Retour au numéro
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