HLA typing associated with hepatitis B E antigen seroconversion in children with chronic hepatitis B virus infection: A long-term prospective sibling cohort study in Taiwan - 10/08/11

Doi : 10.1016/j.jpeds.2005.12.025

Jia-Feng Wu, MD ^a,^b,^c, Chen-Hsin Chen, PhD ^a,^b,^c, Rhong-Phong Hsieh ^a,^b,^c, Hsiang-Hung Shih, MD ^a,^b,^c, Yi-Hau Chen, PhD ^a,^b,^c, Chi-Rong Li ^a,^b,^c, Chih-Yao Chiang ^a,^b,^c, Wen-Yi Shau, MD ^a,^b,^c, Yen-Hsuan Ni, MS, PhD ^a,^b,^c, Huey-Ling Chen, MD, PhD ^a,^b,^c, Hong-Yuan Hsu, MD, PhD ^a,^b,^c, Mei-Hwei Chang, MD ^a,^b,^c,^⁎
^a Departments of Pediatrics and Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
^b Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
^c Graduate Institutes of Epidemiology and Clinical Medicine, National Taiwan University, Taipei, Taiwan.

Reprint requests: Mei-Hwei Chang, MD, Department of Pediatrics, National Taiwan University Hospital, 7 Chung-Shan S. Road, Taipei, Taiwan.

Résumé

Objective

To conduct a prospective cohort study to clarify the relationship between human leukocyte antigen (HLA) polymorphisms and the seroconversion of hepatitis B e antigen (HBeAg).

Study design

In the prospective cohort study, 81 HBeAg-positive children with chronic hepatitis B virus (HBV) infection from 40 unrelated families were recruited and followed-up regularly for a mean period of 17.70 ± 3.23 years. The association between HLA antigen and the age at HBeAg seroconversion was analyzed using Cox regression model with shared frailties under left truncation and right censorship.

Results

HLA-B61 and HLA-DQB1*0503 antigens predicted a higher HBeAg seroconversion rate (relative incidence = 6.17 and 3.22, P = .024 and .017, respectively). Within-family frailty in our sibling cohort study demonstrated a negligible or a low degree of within-family correlation with spontaneous HBeAg seroconversion in each HLA antigen.

Conclusions

HLA class I antigen B61 and class II antigen DQB1*0503 are associated with earlier HBeAg seroconversion in Taiwanese children with chronic HBV infection.

Le texte complet de cet article est disponible en PDF.

Abbreviations : CTL, HBeAg, HbsAg, HBV, HLA, MHC

Plan

General Characteristics of the Study Population

Association Between HLA Markers and Spontaneous HBeAg Seroconversion

Within-Family Frailty of HLA Markers

Discussion

Supported by a grant from the National Science Council, ROC (NSC-87-2314-B002-128) and in part by the Academia Sinica Thematic Project (grant AS91ISS1PP). The authors have no potential, perceived, or real conflict of interest.

Export

Vol 148 - N° 5

P. 647 - mai 2006 Retour au numéro

Article précédent

50 years ago in the journal of pediatrics : Diffuse interstitial fibrosis of the lungs in children
Lisa R. Young

| Article suivant

Acute liver failure in children: The first 348 patients in the pediatric acute liver failure study group
Robert H. Squires, Benjamin L. Shneider, John Bucuvalas, Estella Alonso, Ronald J. Sokol, Michael R. Narkewicz, Anil Dhawan, Philip Rosenthal, Norberto Rodriguez-Baez, Karen F. Murray, Simon Horslen, Martin G. Martin, M. James Lopez, Humberto Soriano, Brendan M. McGuire, Maureen M. Jonas, Nada Yazigi, Ross W. Shepherd, Kathleen Schwarz, Steven Lobritto, Daniel W. Thomas, Joel E. Lavine, Saul Karpen, Vicky Ng, Deirdre Kelly, Nancy Simonds, Linda S. Hynan

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

HLA typing associated with hepatitis B E antigen seroconversion in children with chronic hepatitis B virus infection: A long-term prospective sibling cohort study in Taiwan - 10/08/11

Résumé

Objective

Study design

Results

Conclusions

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL