Cognitive Function in Adolescence: Testing for Interactions Between Breast-Feeding and FADS2 Polymorphisms - 10/08/11
, Beben Benyamin, Ph.D. a, Narelle K. Hansell, Ph.D. a, b, Grant W. Montgomery, Ph.D. a, Nicholas G. Martin, Ph.D. a, b, Margaret J. Wright, Ph.D. a, b, Timothy C. Bates, Ph.D. a, c
Correspondence to Nicolas W. Martin, M.Sc., Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, Brisbane, QLD 4029, AustraliaRésumé |
Objectives |
Breast-fed C-allele carriers of the rs174575 single nucleotide polymorphism in the fatty acyl desaturase 2 (FADS2) gene have been reported to show a 6.4 to 7 IQ point advantage over formula-fed C-allele carriers, with no effect of breast-feeding in GG carriers. An Australian sample was examined to determine if an interaction between breast-feeding and the rs174575 single nucleotide polymorphism had any effect on IQ.
Method |
This hypothesis was tested in more than 700 families of adolescent twins assessed for IQ and breast-feeding, birth weight, and FADS2 polymorphisms, and parental socioeconomic status and education, and maternal FADS2 status.
Results |
No significant evidence for a moderating effect on IQ of rs174575 C-carrier status and breast-feeding was found, and there no effects of maternal FADS2 status on offspring IQ. In addition, no main effects of any FADS2 polymorphisms on IQ were found when the genotype was kept as two-homozygote and one-heterozygote categories and indeed no evidence for effects of breast-feeding on IQ scores after controlling for parental socioeconomic status and education. The investigation was extended to two additional FADS2 polymorphisms (rs1535 and rs174583), but again, although these polymorphisms code alleles affecting fatty acid metabolism, no main or interaction effects were found on IQ.
Conclusion |
These results support the view that apparent effects of breast-feeding on IQ reflect differential likelihood of breast-feeding as a function of parental education and did not support the predicted interaction effect of FADS2 and breast-feeding on IQ.
Le texte complet de cet article est disponible en PDF.Key Words : Breast-feeding, IQ gene-environment interactions, fatty acid metabolism, FADS2
Plan
| This work was supported by the Australian Research Council (A7960034, A79906588, A79801419, DP0212016, DP0343921), The Human Frontier Science Program (RG0154.1998-B), and the National Health and Medical Research Council's Medical Bioinformatics Genomics Proteomics Program (389891). |
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| Supplemental material cited in this article is available online. |
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| Disclosure: Mr. N. W. Martin has received support from the Office of the Chief Scientist, Scotland, a scholarship from the Australian-New Zealand Trust, and by a grant from the Templeton Foundation (13575). Drs. Benyamin, Hansell, Montgomery, N. G. Martin, Wright, and Bates report no biomedical financial interests or potential conflicts of interest. |
Vol 50 - N° 1
P. 55 - janvier 2011 Retour au numéro
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