Superantigens in dermatology - 10/08/11
, Frederick A. Pereira, MD a, b, William Rietkerk, MD, MBA a, Bijan Safai, MD a
Reprint requests: Edgar S. Macias, MD, New York Medical College, 1901 First Ave, New York, NY 10029.Abstract |
Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs. They are linked to a variety of conditions, ranging from toxic shock syndrome to recurrent toxin-mediated perineal erythema. The early recognition of signs and symptoms of SAg-mediated illnesses is important to ensure prompt medical treatment.
Le texte complet de cet article est disponible en PDF.Key words : bacterial toxins, Kawasaki disease, superantigens, toxic shock syndrome
Abbreviations used : AD, APC, ET, GAS, KD, MHC, MRSA, NMTSS, PMBC, REDD, RTPE, SAg, SE, SMEZ, SPE, SSSS, STSS, Th, TSS, TSSLED, TSST-1, SS, CTCL
Plan
Vol 64 - N° 3
P. 455-472 - mars 2011 Retour au numéro
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