Reference Values for Myocardial Two-Dimensional Strain Echocardiography in a Healthy Pediatric and Young Adult Cohort - 10/08/11
, Annelies M.C. Mavinkurve-Groothuis, MD b, Marlieke Barends, BSc a, Arie van Dijk, MD, PhD c, Ton Feuth, MSc d, Chris de Korte, PhD e, Livia Kapusta, MD PhD a, f
Reprint requests: Karen A. Marcus, MD, Children’s Heart Centre, Radboud University Nijmegen Medical Centre, M325.04.004 KG, PO Box 9101, 6500 HB Nijmegen, The Netherlands.Abstract |
Background |
The accurate evaluation of intrinsic myocardial contractility in children with or without congenital heart disease (CHD) has turned out to be a challenge. Two-dimensional strain echocardiographic (2DSTE) imaging or two-dimensional speckle-tracking echocardiographic imaging appears to hold significant promise as a tool to improve the assessment of ventricular myocardial function. The aim of this study was to estimate left ventricular myocardial systolic function using 2DSTE imaging in a large cohort consisting of healthy children and young adults to establish reference strain values.
Methods |
Transthoracic echocardiograms were acquired in 195 healthy subjects (139 children, 56 young adults) and were retrospectively analyzed. Longitudinal, circumferential, and radial peak systolic strain values were determined by means of speckle tracking. Nonlinear regression analysis was performed to assess the effect of aging on these 2DSTE parameters.
Results |
There was a strong, statistically significant second-order polynomial relation (P < .001) between global peak systolic strain parameters and age. Global peak systolic strain values were lowest in the youngest and oldest age groups.
Conclusion |
This is the first report to establish age-dependent reference values per cardiac segment for myocardial strain in all three directions assessed using 2DSTE imaging in a large pediatric and young adult cohort. There is a need to use age-specific reference values for the adequate interpretation of 2DSTE measurements.
Le texte complet de cet article est disponible en PDF.Keywords : Child, Healthy, Reference value, Speckle tracking, Two-dimensional strain echocardiography
Abbreviations : CHD, CI, DTI, LVETc, LVM, MRI, SR, 2DSTE, VCFc
Plan
Vol 24 - N° 6
P. 625-636 - juin 2011 Retour au numéro
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