MR Relaxation in Multiple Sclerosis - 11/08/11

Doi : 10.1016/j.nic.2008.09.007

A.L. MacKay, DPhil ^a,^b,^c,^⁎ , I.M. Vavasour, PhD ^a,^c, A. Rauscher, PhD ^a,^c, S.H. Kolind, MSc ^b,^c, B. Mädler, PhD ^c,^d, G.R.W. Moore, MD ^c,^e, A.L. Traboulsee, MD ^c,^f, D.K.B. Li, MD ^a,^c, C. Laule, PhD ^a,^c
^a Department of Radiology, University of British Columbia, Vancouver, BC, Canada
^b Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada
^c UBC MRI Research Centre, Department of Radiology, Room M10, Purdy Pavilion, UBC Hospital, 2221 Wesbrook Mall, Vancouver BC V6T 2B5 Canada
^d Philips Healthcare, Vancouver BC Canada
^e Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
^f Department of Medicine, University of British Columbia, Vancouver, BC, Canada

Corresponding author. UBC MRI Research Centre, Department of Radiology, Room M10, Purdy Pavilion, UBC Hospital, 2221 Wesbrook Mall, Vancouver BC V6T 2B5 Canada.

Abstract

This article provides an overview of relaxation times and their application to normal brain and brain and cord affected by multiple sclerosis. The goal is to provide readers with an intuitive understanding of what influences relaxation times, how relaxation times can be accurately measured, and how they provide specific information about the pathology of MS. The article summarizes significant results from relaxation time studies in the normal human brain and cord and from people who have multiple sclerosis. It also reports on studies that have compared relaxation time results with results from other MR techniques.

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Keywords : Relaxation, T₁, T₂, Brain, Multiple sclerosis