Microarrayed recombinant allergens for diagnostic testing - 11/08/11
Reprint requests: Wayne G. Shreffler, MD, PhD, Massachusetts General Hospital, Food Allergy Center at MGH and the Center for Immunology and Inflammatory Diseases, 55 Fruit St, Boston, MA 02114.Abstract |
The development of protein microarray–based immunoassays and the availability of recombinant allergens have, to a significant extent, emerged together over the past decade. Their long-anticipated wider application to allergy diagnosis has recently begun to accelerate. This review discusses some of the strengths and weaknesses of molecularly defined allergy testing and the microarray platform. Several recent applications of microarray assays to allergy testing are also summarized. Promising findings, particularly in the context of food and latex allergy, point to the potential for greater resolution between clinical reactivity and asymptomatic sensitization with this platform.
Le texte complet de cet article est disponible en PDF.Key words : Microarray-based immunoassay, microarray-based allergy testing, component-resolved diagnostics, molecular allergy diagnosis
Abbreviations used : CRD, ISAC, SPT
Plan
| Series editors: Joshua A. Boyce, MD, Fred Finkelman, MD, William T. Shearer, MD, PhD, and Donata Vercelli, MD |
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| Terms in boldface and italics are defined in the glossary on page 844. |
Vol 127 - N° 4
P. 843-849 - avril 2011 Retour au numéro
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- Recombinant allergens for specific immunotherapy
- Oliver Cromwell, Dietrich Häfner, Andreas Nandy
- Microarrayed recombinant allergens for diagnostic testing
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