Microcirculatory Dysfunction in Sepsis - 11/08/11
Doi : 10.1016/j.ccell.2010.12.004
David J. Lundy, MD a, ⁎ 
, Stephen Trzeciak, MD, MPH b
, Stephen Trzeciak, MD, MPH b a Department of Surgery, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Three Cooper Plaza, Suite 411, Camden, NJ 08103, USA
b Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza, D363, Camden, NJ 08103, USA
Corresponding author.Résumé |
This article discusses the role of microcirculatory dysfunction in the pathophysiology of sepsis, reviewing the role of the endothelium in modulating microcirculatory flow, discussing the function of nitric oxide in mediating microcirculatory blood flow, and outlining means of evaluating microcirculatory function in septic patients. Finally, potential novel therapies and challenges in treating microcirculatory dysfunction in septic patients are discussed.
Le texte complet de cet article est disponible en PDF.Keywords : Microcirculation, Sepsis, Severe sepsis, Septic shock, Organ failure
Plan
| A version of this article was previously published in Critical Care Clinics 25:4. |
© 2011
Elsevier Inc. Tous droits réservés.
Vol 23 - N° 1
P. 67-77 - mars 2011 Retour au numéro
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