Allergic skin diseases - 11/08/11

Doi : 10.1016/j.jaci.2009.05.039

Luz S. Fonacier, MD ^a, Stephen C. Dreskin, MD, PhD ^b, Donald Y.M. Leung, MD, PhD ^c,^⁎
^a Winthrop University Hospital, Mineola, NY
^b University of Colorado Denver, Aurora, Colo
^c National Jewish Health, Denver, Colo

Reprint requests: Donald Y. M. Leung, MD, PhD, National Jewish Health, 1400 Jackson St, Room K926i, Denver, CO 80206.

Résumé

The skin is one of the largest immunologic organs and is affected by both external and internal factors, as well as innate and adaptive immune responses. Many skin disorders, such as atopic dermatitis, contact dermatitis, urticaria, angioedema, psoriasis, and autoimmune blistering disorders, are immune mediated. Most of these diseases are chronic, inflammatory, and proliferative, in which both genetic and environmental factors play important roles. These immunologic mechanisms might have implications for potential targets of future therapeutic interventions.

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Key words : Allergic contact dermatitis, autoimmune blistering disease, atopic dermatitis, eczema, immune-mediated skin disorders, irritant contact dermatitis, psoriasis, urticaria

Abbreviations used : ACD, AD, AMP, ASST, BHR, BP, CAPB, CD, CIU, CU, DC, EH, FDA, HBD, ICD, IDEC, IVIG, LC, NACDG, PDC, PPD, PV, ROAT, SCD, TLR, T.R.U.E. TEST, TSLP

Plan

Disclosure of potential conflict of interest: L. S. Fonacier has received research support from Novartis-Genentech, Dyax, Lev, Allerderm, and Alcom; is on the Board of Regents of the American College of Allergy, Asthma & Immunology; is President of the Long Island Allergy Society; and is past President of the International Association of Filipino Allergists and Immunologists. S. C. Dreskin has received research support from the National Institutes of Health and has provided expert witness testimony on antibiotic allergy and vaccine allergy. D. Y. M. Leung has declared that he has no conflict of interest.