EUS is still superior to multidetector computerized tomography for detection of pancreatic neuroendocrine tumors - 11/08/11
Reprint requests: Marcia Irene Canto, MD, MHS, Division of Gastroenterology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, 1830 East Monument Street, Room 427, Baltimore, MD 21205, USA.Résumé |
Background |
The role of EUS for detection of pancreatic neuroendocrine tumors (PNETs) is not clearly defined in institutions that use multidetector CT for pancreatic imaging.
Objective |
The aims of this study were to (1) compare the detection rates of EUS and CT by type and size of PNET and calculate the incremental benefit of EUS over CT, (2) evaluate the CT detection rate for PNETs adjusted for improved CT technology over time, and (3) determine the factors associated with CT-negative PNETs.
Design |
Retrospective single-center cohort study.
Setting |
Johns Hopkins Hospital.
Patients |
Patients with pathologically proven PNETs with preoperative CT. Incidentally found PNETs (resection specimens) and those without Johns Hopkins Hospital CT imaging were excluded.
Main Outcome Measurement |
Detection rates of CT and EUS were compared by using pathology as the reference standard.
Results |
In 217 patients (with 231 PNETs) studied, CT detected 84% of tumors (54.3% of insulinomas). The sensitivity of CT for the detection of PNETs significantly increased with improvement in CT technology (P = .02; χ2 for trend). CT was more likely to miss lesions <2 cm (P = .005) and insulinomas (P < .0001). In 56 patients who had both CT and EUS, the sensitivity of EUS was greater than CT (91.7% vs 63.3%; P = .0002), particularly for insulinomas (84.2% vs 31.6%; P = .001). EUS detected 20 of 22 CT-negative tumors (91%).
Limitations |
Retrospective nonrandomized design and referral bias.
Conclusions |
The detection rate of CT has significantly improved over time. CT-negative tumors are small and more likely to be insulinomas. A sequential approach of CT followed by EUS can detect most PNETs. EUS is a more sensitive initial test for the detection of suspected insulinomas.
Le texte complet de cet article est disponible en PDF.Abbreviations : JHH, MDCT, PNETs, VIPomas
Plan
| DISCLOSURE: All authors disclosed no financial relationships relevant to this publication. |
|
| If you would like to chat with an author of this article, you may contact Dr Canto at mcanto@jhmi.edu. |
|
| See CME section; p. 798. |
Vol 73 - N° 4
P. 691-696 - avril 2011 Retour au numéro
Article précédent
- Endoscopic radiofrequency ablation combined with endoscopic resection for early neoplasia in Barrett's esophagus longer than 10 cm
- Lorenza Alvarez Herrero, Frederike G.I. van Vilsteren, Roos E. Pouw, Fiebo J.W. ten Kate, Mike Visser, Cornelis A. Seldenrijk, Mark I. van Berge Henegouwen, Paul Fockens, Bas L.A.M. Weusten, Jaques J.G.H.M. Bergman
- Walk closer or carry big glass? Comparing EUS and multidetector CT
- Michael M. Owens
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?