Establishing diagnostic features for identifying the mucosa and submucosa of normal and cancerous gastric tissues by multiphoton microscopy - 11/08/11
⁎, Shuangmu Zhuo, PhD , Gang Chen, MD , Jun Yan, MD, Hongquan Yang, BSc, Nenrong Liu, MSc, Liqin Zheng, MSc, Xingshan Jiang, PhD, Shusen Xie, BScReprint requests: Jianxin Chen, PhD, Fujian Normal University, 8 Shangsan Road, Fuzhou, China 350007Résumé |
Background |
Establishing diagnostic features is essential and significant for developing multiphoton endoscopy to make an early diagnosis of gastric cancer at the cellular level. Until now, these diagnostic features have not been clearly described and understood.
Design |
Study of diagnostic features based on multiphoton microscopy (MPM).
Objective |
Establishing diagnostic features to identify the mucosa and submucosa of human normal and cancerous gastric tissues by investigating their multiphoton microscopic images.
Setting |
Fujian Normal University and Fujian Provincial Tumor Hospital.
Patients |
Ten pairs of normal and cancerous specimens were obtained from 10 patients (ages 51-68 years) undergoing radical gastrectomy.
Interventions |
MPM was performed on specimens.
Main Outcome Measurements |
Establishment of diagnostic features.
Results |
MPM has the ability to exhibit not only the mucosal and submucosal microstructures of normal and cancerous gastric tissues but also the distribution and content of abnormal cells in these 2 layers. More importantly, it can provide the diagnostic features to qualitatively and quantitatively differentiate between normal and cancerous gastric tissues.
Limitations |
The selection bias and preparation of specimen.
Conclusions |
These findings provide the groundwork for further establishing diagnostic criteria.
Le texte complet de cet article est disponible en PDF.Abbreviations : GGO, MPM, SHG, TPEF
Plan
| DISCLOSURE: Drs Chen, Zhuo, and Jiang were supported by the National Natural Science Foundation of China (grants 30970783, 60908043), the Program for New Century Excellent Talents in University (grant NCET-07-0191), the Natural Science Funds for Distinguished Young Scholar in Fujian Province (grant 2009J06031). Dr Yan was supported by the Natural Science Foundation of Fujian Province (grant 2010J01136). All authors disclosed no financial relationships relevant to this publication. |
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| If you would like to chat with an author of this article, you may contact Dr Chen at chenjianxin@fjnu.edu.cn, or Dr Yan at ynjun@yahoo.com. |
Vol 73 - N° 4
P. 802-807 - avril 2011 Retour au numéro
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