Long-term Safety Concerns with Proton Pump Inhibitors - 12/08/11
, David Neil Roberts, MD, William M. Tierney, MD
Reprint requests should be addressed to Tauseef Ali, MD, 1360 WP. 920 SL Young Blvd, Oklahoma City, OK 73104Abstract |
Proton pump inhibitors (PPIs) are among the most widely prescribed medications worldwide. Their use has resulted in dramatic improvements in treatment of peptic ulcer disease and gastroesophageal reflux disease. Despite an acceptable safety profile, mounting data demonstrate concerns about the long-term use of PPIs. To provide a comprehensive review regarding the concerns of long-term PPI use, a literature search was performed to identify pertinent original and review articles. Despite study shortcomings, the collective body of information overwhelmingly suggests an increased risk of infectious complications and nutritional deficiencies. Data regarding any increased risk in gastric or colon malignancy are less convincing. PPIs have revolutionized the management and complications of acid-related disorders with a high margin of safety; however, with the data available, efforts to reduce the dosing of or discontinue the use of PPIs must be reassessed frequently.
Le texte complet de cet article est disponible en PDF.Keywords : Acid-suppression therapy, Long-term safety, Proton pump inhibitors, Side effects
Plan
| Funding: None. |
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| Conflict of Interest: None of the authors have any conflicts of interest associated with the work presented in this manuscript. |
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| Authorship: All authors had access to the data and played a role in writing this manuscript. |
Vol 122 - N° 10
P. 896-903 - octobre 2009 Retour au numéro
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