Comparison of Dual Source Computed Tomography Versus Intravascular Ultrasound for Evaluation of Coronary Arteries at Least One Year After Cardiac Transplantation - 12/08/11
, Stephan Achenbach, MD a, Michael Weyand, MD b, Philip Raum, MD b, Mohamed Marwan, MD a, Tobias Pflederer, MD a, Werner G. Daniel, MD a, Rene Tandler, MD b, Markus Kondruweit, MD b, Dieter Ropers, MD a
Corresponding author: Tel: 49-9131-853-5000; fax: 49-9131-853-5303Résumé |
This study evaluated the ability of dual-source computed tomography (DSCT) to detect coronary allograft vasculopathy (CAV) in heart transplant recipients using intravascular ultrasound (IVUS) as the standard of reference. Thirty patients with heart transplants (81% men, mean age 40 years) underwent DSCT (330-ms gantry rotation, 2 × 64 × 0.6-mm collimation, 60- to 80-ml contrast agent, no additional β blockers) before invasive coronary angiography including IVUS of 1 vessel. Detection of CAV by DSCT was qualitatively defined as the presence of any coronary plaque. Mean heart rate during dual-source computed tomographic scanning was 80 ± 14 beats/min. Four hundred fifty-nine segments with a vessel caliber ≥1.5 mm according to quantitative coronary angiography were evaluated in 30 patients. Of these, 96% were considered to have excellent or good image quality. IVUS detected CAV in 17 of 30 patients (57%) and in 41 of 110 coronary segments (37%). Compared to IVUS, sensitivity, specificity, positive and negative predictive values for the detection of CAV by DSCT were 85%, 84%, 76%, and 91%, respectively. In conclusion, DSCT permits the investigation of transplant recipients concerning the presence of CAV with good image quality and high diagnostic accuracy.
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| This work was supported by Grant 01 EV 0708 from Bundesministerium für Bildung und Forschung, Berlin, Germany. |
Vol 104 - N° 10
P. 1351-1356 - novembre 2009 Retour au numéro
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