Two-dimensional strain analysis in patients with hypertrophic cardiomyopathy and normal systolic function: A 12-month follow-up study - 12/08/11
, Dimitrios Farmakis, MD, Costantinos Papadopoulos, MD, Ignatios Ikonomidis, MD, John Parissis, MD, Aggelos Rigopoulos, MD, Efstathios K. Iliodromitis, MD, Dimitrios Th. Kremastinos, MDRésumé |
Background |
Although left ventricular (LV) and left atrial (LA) echo indices may reliably reflect loading conditions in patients with hypertrophic cardiomyopathy (HCM), little is known about 2-dimensional strain imaging. We evaluated LV and LA 2-dimensional strain imaging in relation to long-term outcome in patients with HCM.
Methods |
Fifty consecutive patients (58% men, aged 51 ± 18 years) with familial HCM and normal LV ejection fraction underwent 2-dimensional LV and LA strain imaging; total LA strain was defined as the sum of maximum positive and maximum negative atrial strain. Patients were followed up for 12 months for cardiovascular events, defined as death or hospitalization for cardiovascular causes.
Results |
Twenty patients (40%) experienced an event after a median time of 98 days: 2 (4%) died and 18 (36%) were hospitalized. In multivariate analysis, total LA strain was the strongest predictor of 12-month outcome (odds ratio 0.858, 95% CI 0.771-0.954, P = .005); a cutoff of 21% predicted events with 90% sensitivity and 86% specificity. Total LA strain was also an independent predictor of atrial fibrillation requiring hospitalization (odds ratio 0.853, 95% CI 0.748-0.972, P = .017).
Conclusions |
In patients with HCM and normal systolic function, total LA strain predicts 12-month outcome in terms of death and/or hospitalization.
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Vol 158 - N° 3
P. 444-450 - septembre 2009 Retour au numéro
Article précédent
- The effects of eplerenone on length of stay and total days of heart failure hospitalization after myocardial infarction in patients with left ventricular systolic dysfunction
- Mihai Gheorghiade, Sadiya Khan, John E.A. Blair, Matthew E. Harinstein, Henry Krum, Robin Mukherjee, Bertram Pitt, for the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival (EPHESUS) Investigators
- Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy
- Vy-Van Le, Marco V. Perez, Matthew T. Wheeler, Jonathan Myers, Ingela Schnittger, Euan A. Ashley
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