Screening for colorectal neoplasms has become the standard of care in advanced medical settings worldwide. Identifying asymptomatic colorectal neoplastic lesions has been shown to reduce colorectal cancer incidence and the overall cost of medical care. Clinicians have several alternatives at their disposal as they consider screening for their respective patient population. Two important methods to consider are optical colonoscopy and computed tomographic colonography (CTC). The purpose of this article is to make the case that gastroenterologists should read CTC. Central to the argument that gastroenterologists read CTC is the benefit of experience with video-assisted colonic imaging and the physician-patient relationship.