Early Umbilical Cord Clamping Contributes to Elevated Blood Lead Levels among Infants with Higher Lead Exposure - 12/08/11
, Raymond Fornes, MS †, Lynnette M. Neufeld, PhD ‡, Gilberto Tena Alavez, MD §, Raúl Eguía-Líz Cedillo, MD §, Kathryn G. Dewey, PhD ⁎ 
From the Department of Nutrition, Program in International and Community Nutrition, University of California, Davis, California Reprint requests: Kathryn G. Dewey, PhD, Department of Nutrition, Program in International and Community Nutrition, University of California, One Shields Avenue, Davis, CA 95616-8669.Résumé |
Objective |
To investigate whether infant iron status, modified by umbilical cord clamping time and infant feeding mode, affected infant blood lead concentration at 6 months of age.
Study design |
Participants were a subset of women and their infants randomized to receive early (10 seconds) or delayed (2 minutes) umbilical cord clamping and were monitored to 6 months postpartum in Mexico City. Iron and lead status was analyzed in maternal, placental, and 6-month infant blood samples. Baseline maternal lead exposure data and infant feeding data at 2, 4, and 6 months were collected.
Results |
In the total sample, maternal blood lead concentration, infant ferritin, and breast-feeding practices predicted infant blood lead concentration. Among infants with higher placental blood lead concentration and breast-fed infants not receiving any iron-fortified formula or milk at 6 months, early clamping increased infant blood lead concentration, an effect mediated in part via decreased infant iron status.
Conclusions |
Early cord clamping, by decreasing infant iron status, contributes to higher blood lead concentrations at 6 months of age among infants at high risk.
Le texte complet de cet article est disponible en PDF.Abbreviations : BSI, DMT1, EBL, FM, Hgb, ID, NFM, TfR
Plan
| Supported by the Thrasher Research Fund and a U.S. Fulbright grant. |
Vol 151 - N° 5
P. 506-512 - novembre 2007 Retour au numéro
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