Nebulization associated with Bi-level noninvasive ventilation: Analysis of pulmonary radioaerosol deposition - 12/08/11
, Geovanna Cabral a, Paulo Almeida Filho a, Kamary C. Silva a, Valdecir C. Galindo Filho a, Patrícia E.M. Marinho a, Andrea Lemos a, Verônica F. Parreira b
Corresponding author. Tel.: +558199738965; fax: +558121268490.Summary |
Nebulization associated with noninvasive ventilation is used in emergency services and intensive care units.
Purposes |
To compare pulmonary radioaerosol deposition during jet nebulization associated to noninvasive ventilation versus spontaneous breathing nebulization; to measure the rate of lung depuration and the correlation between lung deposition, inspiratory flow and tidal volume (Vt) using scintigraphy.
Subjects |
Thirteen healthy volunteers (with normal spirometry), mean age (23.3±1.49) years, body mass index 21.2±2.3kg/m2.
Methods |
Nebulization was performed in spontaneous breathing and associated with bi-level noninvasive ventilation (inspiratory pressure=12cm H2O, expiratory pressure=5cm H2O). The radioaerosol used in the nebulization was technetium (Tc99m) with diethylene triamine penta acetic acid, generated over a period of 9min in a jet nebulizer. Analysis was performed through scintigraphy. Statistical analysis was performed by analysis of variance (for repeated measures), Bonferroni method, Student’s t-test and Person’s correlation.
Results |
There was a decrease in radioaerosol lung deposition with nebulization associated to noninvasive ventilation (mean counts in spontaneous breathing 200,510+11,012 and mean counts in noninvasive ventilation 106,093+2811 (
). During spontaneous breathing nebulization there was a significant correlation between Vt and radioaerosol deposition (
, 
), also between inspiratory flow and radioaerosol deposition in the lungs (
, 
). However, there was no correlation between Vt and pulmonary deposition of radioaerosol in bi-level noninvasive ventilation nebulization (
).
Conclusion |
During nebulization with noninvasive ventilation in healthy volunteers, there was an increase in Vt associated to a higher inspiratory flow rate, without resulting in a significant increase in pulmonary radioaerosol deposition.
Le texte complet de cet article est disponible en PDF.Keywords : Nebulization, Noninvasive ventilation, Pulmonary ventilation
Plan
Vol 100 - N° 4
P. 721-728 - avril 2006 Retour au numéro
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