Postmenopausal hormone therapy and incident urinary incontinence in middle-aged women - 12/08/11
, Gary C. Curhan, MD, ScD a, b, c, Neil M. Resnick, MD d, Francine Grodstein, ScD a, c
Reprints: Mary Townsend, ScD, Channing Laboratory, 181 Longwood Ave, Boston, MA 02115Résumé |
Objective |
The objective of the study was to examine the association of hormone therapy with incident urinary incontinence (UI) in postmenopausal women aged 37-54 years in the Nurses' Health Study II.
Study Design |
Participants reported use of hormone therapy, including hormone type, on biennial questionnaires from 1989 to 2001. Among 7341 postmenopausal women reporting no UI in 2001, we identified 1026 women who developed UI at least monthly between 2001 and 2003. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Results |
Women currently using hormone therapy had 1.39-fold (95% CI, 1.16-1.67) increased odds of incident UI, compared with women who never used hormone therapy. ORs were similar in current users of oral estrogen alone (OR, 1.35, 95% CI, 1.03-1.78) and oral estrogen with progestin (OR, 1.37, 95% CI, 1.13-1.67).
Conclusion |
These findings suggest an increased risk of UI associated with use of postmenopausal hormone therapy in younger postmenopausal women.
Le texte complet de cet article est disponible en PDF.Key words : epidemiology, hormone replacement therapy, menopause, urinary incontinence
Plan
| Cite this article as: Townsend MK, Curhan GC, Resnick NM, et al. Postmenopausal hormone therapy and incident urinary incontinence in middle-aged women. Am J Obstet Gynecol 2009;200:86.e1-86.e5. |
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| This study was supported in part by Grants DK62438 and CA50385 from the National Institutes of Health and the Yerby Postdoctoral Fellowship Program (to M.K.T.). |
Vol 200 - N° 1
P. 86.e1-86.e5 - janvier 2009 Retour au numéro
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