Transdermal scopolamine patch in addition to ondansetron for postoperative nausea and vomiting prophylaxis in patients undergoing ambulatory cosmetic surgery - 13/08/11
: Assistant Professor, Vimala Ramesh, MD b : Staff Anesthesiologist, Bupesh Kaul, MD a : Associate Professor of Anesthesiology, Patricia Dalby, MD a : Assistant Professor, Kenneth Shestak, MD c : Professor of Surgery, Manuel C. Vallejo, MD a : Associate Professor of AnesthesiologyAbstract |
Study Objective |
To determine the efficacy of transdermal scopolamine in addition to ondansetron in decreasing the incidence of postoperative nausea and vomiting (PONV).
Design |
Randomized controlled trial.
Setting |
Academic hospital.
Patients |
126 ASA physical status I and II patients undergoing outpatient plastic surgery with three or more risk factors for PONV.
Interventions |
Patients were randomly assigned to one of two groups to receive (Group 1) a transdermal scopolamine (TDS) patch or (Group 2), a placebo patch two hours before surgery.
Measurements |
Occurrence of vomiting, severity of nausea using a visual analog scale (VAS), rescue medication, pain intensity and pain medications, and side effects were recorded every hour until discharge from hospital, then every 4 hours thereafter for a total of 24 hours.
Main Results |
A statistically significant reduction in postoperative nausea between 8 and 24 hours in patients receiving TDS was noted.
Conclusions |
Transdermal scopolamine in addition to ondansetron benefits patients at high risk for PONV undergoing outpatient plastic surgery for up to 20 hours after surgery.
Le texte complet de cet article est disponible en PDF.Keywords : Cosmetic surgery, Postoperative nausea and vomiting, Postoperative pain, Scopolamine, Transdermal drug delivery
Plan
| ☆ | Supported in party by Baxter HealthCare, Deerfield, IL, which provided the transdermal scopolamine and placebo patches used in this study. |
Vol 21 - N° 4
P. 249-252 - juin 2009 Retour au numéro
Article précédent
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