Host Defense and Pathogenesis in Staphylococcus aureus Infections - 13/08/11
Doi : 10.1016/j.idc.2008.10.003
Frank R. DeLeo, PhD a, ⁎ 
, Binh An Diep, PhD b, Michael Otto, PhD a
, Binh An Diep, PhD b, Michael Otto, PhD a a Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
b Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, 1001 Potrero Avenue, Building 30 Room 3300, San Francisco, CA 94110, USA
Corresponding author.Abstract |
Staphylococcus aureus is the most abundant cause of bacterial infections in the United States. As such, the pathogen has devised means to circumvent destruction by the innate immune system. Neutrophils are a critical component of innate immunity and the primary cellular defense against S aureus infections. This article reviews human neutrophil function in the context of S aureus virulence mechanisms and provides an overview of community-associated methicillin-resistant S aureus pathogenicity.
Le texte complet de cet article est disponible en PDF.Keywords : Staphylococcus, Neutrophil, Innate immunity, Virulence
Plan
| This work was supported by the Intramural Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health. |
© 2009
Publié par Elsevier Masson SAS.
Vol 23 - N° 1
P. 17-34 - mars 2009 Retour au numéro
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