Staphylococcus aureus: A Community Pathogen - 13/08/11

Doi : 10.1016/j.idc.2008.10.002

Loren G. Miller, MD, MPH ^a,^b,^c,^⁎ , Sheldon L. Kaplan, MD ^d
^a Harbor-UCLA Medical Center, Division of Infectious Diseases, Infection Control Program, 1000 W. Carson Street, Box 466, Torrance CA 90509, USA
^b Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA, USA
^c David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
^d Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital MC3-2371, Infectious Disease Service, 6621 Fannin, Houston, TX 77030, USA

Corresponding author. Harbor-UCLA Medical Center, Division of Infectious Diseases, Infection Control Program, 1000 W. Carson Street, Box 466, Torrance CA 90509.

Abstract

Staphylococcus aureus is a common human pathogen. S aureus infections most commonly clinically manifest as skin infections. There has been much interest in S aureus infections in the community over the past decade because of the rise of community-associated methicillin-resistant S aureus (CA-MRSA) infections, which have emerged globally over a relatively short period of time. In contrast to health care-associated methicillin resistant S aureus (HA-MRSA), circulating strains of CA-MRSA have characteristic pathogenesis, strain characteristics, epidemiology, and clinical manifestations that are distinct from HA-MRSA. In fact, CA-MRSA probably behaves more like community-associated methicillin-sensitive S aureus (MSSA). This article reviews current knowledge of the epidemiology and clinical manifestations of community-associated S aureus and CA-MRSA infections.

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Keywords : Staphylococcus aureus, Methicillin-resistance, MRSA, Epidemiology, Clinical syndromes, Community infections