Laparoscopic surgery vs laparotomy for early stage endometrial cancer: long-term data of a randomized controlled trial - 13/08/11
, Angela Falbo, MD a, Tiziana Russo, MD c, Rita Mocciaro, MD a, Eduardo Tartaglia, MD d, Piersandro Tagliaferri, MD b, Pasquale Mastrantonio, MD d
Reprints: Stefano Palomba, MD, Via T. Campanella 182/1, 88100 Catanzaro, ItalyRésumé |
Objective |
The purpose of the study was to compare the long-term safety and efficacy of laparoscopic surgery and laparotomy approaches to early stage endometrial cancer.
Study Design |
This was a prospective long-term extension study of a randomized controlled study that included 84 patients with clinical stage I endometrial cancer (laparoscopic surgery group, 40 women; laparotomy group, 38 women). Safety and efficacy data were evaluated and analyzed by the intention-to-treat principle.
Results |
After a follow-up period of 78 months (interquartile range, 7; range, 19-84 months) and 79 months (interquartile range, 6; range, 22-84 months) for laparoscopic surgery and laparotomy groups, respectively, no difference in the cumulative recurrence rates (8/40 [20.0%] and 7/38 [18.4%]; P = .860) and deaths (7/40 [17.5%] and 6/38 [15.8%] patients; P = .839) was detected between groups. No significant differences in overall (P = .535) and disease-free (P = .512) survival were observed.
Conclusion |
The laparoscopic surgery approach to early stage endometrial cancer is as safe and effective a procedure as the laparotomy approach.
Le texte complet de cet article est disponible en PDF.Key words : endometrial cancer, laparoscopy, laparotomy, surgery, uterine cancer
Plan
| Cite this article as: Zullo F, Palomba S, Falbo A, et al. Laparoscopic surgery vs laparotomy for early stage endometrial cancer: long-term data of a randomized controlled trial. Am J Obstet Gynecol 2009;200:296.e1-296.e9. |
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| Authorship and contribution to the manuscript is limited to the 8 authors indicated. There was no outside funding or technical assistance with the production of this article. |
Vol 200 - N° 3
P. 296.e1-296.e9 - mars 2009 Retour au numéro
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