First-trimester cervical inflammatory milieu and subsequent early preterm birth - 13/08/11
, Marijane A. Krohn, PhD
Reprints: Hyagriv N. Simhan, MD, MSCR, Magee Womens Hospital, Department of OB/GYN, 300 Halket St., Pittsburgh, PA 15213Résumé |
Objective |
Our objective was to explore the relation between the pro- and antiinflammatory cervical cytokine balance in early pregnancy and subsequent early preterm birth.
Study Design |
In this prospective cohort of 218 pregnant women who were enrolled in the first trimester, we assayed cervical concentrations of interleukin-1⍺, -1β, -6, -4, -10, and -13. Based on these cytokines, we categorized subjects into 1 of 3 strata: high proinflammatory/low antiinflammatory, high antiinflammatory/low proinflammatory, or balanced. The primary outcome of interest was preterm birth at < 34 weeks' gestation.
Results |
Women in the high antiinflammatory/low proinflammatory stratum had a subsequent odds ratio for preterm birth < 34 weeks' gestation of 7.7 (95% CI, 4.9-9.1; P = .01), after adjustment for marital status, smoking, bacterial vaginosis, maternal race, and less than high school education.
Conclusion |
Women with a relatively hyporesponsive cervical inflammatory milieu in early pregnancy are at higher risk of subsequent early spontaneous preterm birth.
Le texte complet de cet article est disponible en PDF.Key words : cervix, cytokine, inflammation, preterm birth
Plan
| Cite this article as: Simhan HN, Krohn MA. First-trimester cervical inflammatory milieu and subsequent early preterm birth. Am J Obstet Gynecol 2009;200:377.e1-377.e4. |
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| This study was supported by R01 HD41663 and R01 HD052732. |
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| Authorship and contribution to the article is limited to the 2 authors indicated. There was no outside funding or technical assistance with the production of this article. |
Vol 200 - N° 4
P. 377.e1-377.e4 - avril 2009 Retour au numéro
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